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. 2021 May 12;9:650819. doi: 10.3389/fcell.2021.650819

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Copyright © 2021 Wang, Chen, Chang, Hu, Wang, Xie and Cheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of ATM on the low-dose radiosensitivity of A549 and H460 cells. (A,B) Level of p-ATM in A549 and H460 cells under low-dose radiation. (C,D) siRNA transfection knocked down ATM gene expression in A549 and H460 cells. (E) Decreasing the expression of ATM inhibited the proliferation of A549 and H460. (F) The survival curve of A549 cells fitted by MIRM showed the HRS/IRR phenomenon. (G) The HRS phenomenon of A549 cells was enhanced after ATM knockdown. (H) The survival curves of H460 cells were in line with the traditional LQ model. (I) Radiosensitivity was enhanced in H460 cells after ATM knockdown. *** p< 0.001, ** p< 0.01.