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. 2021 May 12;9:650819. doi: 10.3389/fcell.2021.650819

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Copyright © 2021 Wang, Chen, Chang, Hu, Wang, Xie and Cheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of AMBRA1 and JNK on the radiosensitivity and autophagy of A549 cells. (A,B) siRNA transfection inhibited AMBRA1 gene expression in A549 cells. (C,D) siRNA transfection inhibited JNK gene expression in A549 cells. (E,F) When AMBRA1 and JNK were knocked down in A549 cells, the sensitivity of cells to low-dose radiation increased, and the HRS phenomenon was enhanced. (G,H) When AMBRA1 and JNK were knocked down in A549 cells, cellular autophagy under low-dose radiation was inhibited. *** p< 0.001.