TABLE 1.

Summary of MRI findings in animals with EAE and in healthy controls.

Animal	FUS performed after immunization (days)	Number of T2w-hyperintense lesions			Contrast-enhancement			T2*w signal alteration
		d9 MRI	d14 MRI	d21 MRI	d9 MRI	d14 MRI	d21 MRI	d9 MRI	d14 MRI	d21 MRI
EAE
1*	6	n/a	0	1	n/a	0	0	n/a	0	0
2	6	n/a	0	0	n/a	0	0	n/a	0	0
3	6	n/a	0	0	n/a	0	0	n/a	0	0
4	6	n/a	n/a	n/a	n/a	0	0	n/a	0	0
5	7	0	0	0	0	0	0	0	0	0
6*	7	0	1	2	0	0	0	0	0	0
7	7	1	n/a	n/a	0	0	0	0	0	0
8	7	0	0	0	0	0	0	0	0	0
9*	9	n/a	0	2	n/a	0	0	n/a	0	0
10	9	n/a	0	1	n/a	0	0	n/a	0	0
11*#	9	n/a	1	1	n/a	0	0	n/a	0	0
12	9	n/a	1	1	n/a	0	0	n/a	0	0
Control
1	n/a	n/a	0	n/a	n/a	0	n/a	n/a	0	n/a
2	n/a	n/a	0	n/a	n/a	0	n/a	n/a	0	n/a
3	n/a	n/a	0	n/a	n/a	0	n/a	n/a	0	n/a
4	n/a	n/a	0	n/a	n/a	0	n/a	n/a	0	n/a

The asterisks indicate the animals with hyperintense T2w-lesions that could be co-localized to clusters of activated macrophages and microglia. The hashtag indicates the animal with a T2w-lesion that could be co-localized to a cluster of activated Iba1- and TMEM119-positive resident microglia. FUS, focused ultrasound.