Table 3.
The results of Bayesian Regression model for comparison of expression of PIAS genes in AIDP/CIDP patients and healthy persons (Expressions of PIAS genes have been compared between CIDP cases and controls, AIDP cases and controls, CIDP cases and AIDP cases as well as total patients and total control.
| Number of Samples | PIAS1 | PIAS2 | PIAS3 | PIAS4 | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SE* | Ratio of Mean Expressions | P Value | 95% CI** | SE | Ratio of Mean Expressions | P Value | 95% CI | SE | Ratio of Mean Expressions | P Value | 95% CI | SE | Ratio of Mean Expressions | P Value | 95% CI | ||||||
| CIDP/Control | |||||||||||||||||||||
| Total | 31/50 | 1.10 | 1.12E-03 | 8.2E-14 | -11.99 | -7.62 | 1.02 | 2.22E-03 | 4.5E-13 | -10.84 | -6.78 | 1.10 | 9.02E-03 | 1.7E-08 | -8.98 | -4.61 | 1.01 | 1.05E-02 | 3.8E-09 | -8.58 | -4.58 |
| F | 11/13 | 1.65 | 9.83E-04 | 3.2E-06 | -13.41 | -6.57 | 1.43 | 1.55E-03 | 1.0E-06 | -12.28 | -6.38 | 1.64 | 7.54E-03 | 1.8E-04 | -10.40 | -3.70 | 1.47 | 8.07E-03 | 7.2E-05 | -9.98 | -3.92 |
| M | 20/37 | 1.43 | 1.21E-03 | 1.9E-08 | -12.58 | -6.81 | 1.35 | 3.10E-03 | 1.6E-07 | -11.06 | -5.61 | 1.39 | 1.10E-02 | 2.7E-05 | -9.30 | -3.70 | 1.31 | 1.28E-02 | 1.6E-05 | -8.91 | -3.66 |
| AIDP/Control | |||||||||||||||||||||
| Total | 22/50 | 1.53 | 1.52E-03 | 3.3E-07 | -12.46 | -6.27 | 1.43 | 2.60E-03 | 5.9E-07 | -11.49 | -5.68 | 1.38 | 1.47E-02 | 5.9E-05 | -8.87 | -3.31 | 1.35 | 1.21E-02 | 2.6E-05 | -9.08 | -3.65 |
| F | 6/13 | 2.41 | 1.22E-03 | 1.7E-03 | -14.92 | -4.44 | 2.02 | 1.98E-03 | 7.7E-04 | -13.37 | -4.59 | 2.15 | 1.29E-02 | 1.1E-02 | -10.89 | -1.66 | 2.09 | 1.06E-02 | 8.1E-03 | -11.10 | -2.03 |
| M | 16/37 | 2.00 | 1.73E-03 | 1.1E-04 | -13.30 | -5.05 | 1.95 | 3.54E-03 | 3.5E-04 | -12.18 | -4.11 | 1.77 | 1.76E-02 | 2.8E-03 | -9.46 | -2.19 | 1.76 | 1.42E-02 | 1.8E-03 | -9.76 | -2.52 |
| CIDP/AIDP | |||||||||||||||||||||
| Total | 31/22 | 1.80 | 2.07E+00 | 5.6E-01 | -2.56 | 4.66 | 1.71 | 1.46E+00 | 7.5E-01 | -2.89 | 3.99 | 1.74 | 3.23E+00 | 3.4E-01 | -1.80 | 5.18 | 1.64 | 1.43E+00 | 7.6E-01 | -2.79 | 3.81 |
| F | 11/6 | 2.45 | 1.85E+00 | 7.2E-01 | -4.42 | 6.20 | 2.26 | 2.00E+00 | 6.6E-01 | -3.81 | 5.81 | 2.57 | 4.57E+00 | 4.1E-01 | -3.30 | 7.68 | 2.17 | 2.15E+00 | 6.2E-01 | -3.57 | 5.78 |
| M | 20/16 | 2.38 | 2.24E+00 | 6.3E-01 | -3.66 | 5.99 | 2.31 | 1.35E+00 | 8.5E-01 | -4.27 | 5.13 | 2.26 | 2.87E+00 | 5.0E-01 | -3.07 | 6.11 | 2.18 | 1.25E+00 | 8.8E-01 | -4.11 | 4.75 |
| All Patients/Controls | |||||||||||||||||||||
| Total | 53/50 | 1.23 | 7.33E-04 | 1.0E-09 | -12.92 | -7.91 | 1.17 | 1.78E-03 | 8.9E-09 | -11.51 | -6.75 | 1.41 | 4.54E-03 | 3.8E-06 | -10.65 | -4.91 | 1.22 | 8.49E-03 | 3.0E-06 | -9.36 | -4.40 |
| F | 17/13 | 1.11 | 6.60E-04 | 1.9E-07 | -12.95 | -8.18 | 1.34 | 9.90E-04 | 7.0E-05 | -13.06 | -6.90 | 1.86 | 2.82E-03 | 1.8E-03 | -12.75 | -4.19 | 1.15 | 4.92E-03 | 2.4E-05 | -10.18 | -5.15 |
| M | 36/37 | 1.68 | 7.72E-04 | 3.3E-06 | -13.82 | -6.86 | 1.55 | 2.63E-03 | 1.7E-05 | -11.79 | -5.35 | 1.82 | 6.13E-03 | 5.4E-04 | -11.12 | -3.58 | 1.64 | 1.13E-02 | 7.1E-04 | -9.86 | -3.06 |
*SE, standard error; **95% CI, 95% confidence interval.
Expression of each of PIAS genes was significantly correlated with other PIAS genes in all study groups. Notably, based on the measured correlation coefficients, such correlations were more robust among patients ( Figure 2 ).
Significant P values are shown in bold letters).