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. 2021 May 25;11:10836. doi: 10.1038/s41598-021-90350-z

Table 3.

Factors associated with severe Kikuchi-Fujimoto disease using logistic regression model.

Variables Univariate Multivariable
OR (95% CI) P value OR (95% CI) P value
Age 0.956 (0.910–1.004) 0.073
Sex 0.768
 Female Reference
 Male 1.282 (0.246–6.688)
Systemic symptoms
 Fever duration 1.212 (0.941–1.560) 0.137
 Myalgia 0.150 (0.024–0.946) 0.044 0.035 (0.001–0.792) 0.035
Laboratory findings
 CRP (≥ 100 mg/L) 0.632 (0.092–4.350) 0.641
 LDH (≥ 1000 IU/L) 1.944 (0.192–19.741) 0.574
PET-CT parameters
Total lymph nodes SUVmax (> 9.27) 8.500 (1.335–54.127) 0.023 24.734 (1.323–462.407) 0.032
 Total lymph nodes MTV (> 34.72) 6.667 (1.057–42.065) 0.044
 Total lymph nodes TLG (> 429.99) 10.889 (1.140–103.977) 0.038
 Spleen SUVmean (> 1.79) 11.111 (1.701–72.564) 0.012 37.770 (1.769–806.583) 0.020
 Spleen TLG (> 296.06) 10.500 (1.412–78.059) 0.022
Relapse 1.050 (0.093–11.824) 0.968
Steroid use 0.762 (0.122–4.751) 0.771

OR, Odds ratio; CI, confidential interval; SUVmax, maximum standardized uptake value; SUVmean, mean standardized uptake value; MTV, metabolic tumor volume; TLG, total lesion glycolysis; CRP, C-reactive protein; LDH, lactate dehydrogenase