Table 3.

Spearman correlation evaluating serum biomarkers at baseline in comparison with pulmonary function tests.

	FEV1 %pred	FVC %pred	TLC %pred	DLCO %pred	KCO %pred
IGF-1	− 0.08	− 0.15	− 0.23*	− 0.09	0.02
IGFBP-1	0.05	0.1	0.28**	0.05	− 0.2
IGFBP-2	− 0.13	− 0.12	0.16	− 0.16	− 0.29**
IGFBP-3	0.08	0.06	− 0.01	0.07	0.12
TGF-β1	0.04	− 0.03	− 0.02	0.15	0.03
IL-8	− 0.12	− 0.06	− 0.03	− 0.12	− 0.17
TNF-α	− 0.12	− 0.07	0.14	− 0.08	− 0.15
YKL-40	− 0.3**	− 0.31**	− 0.14	− 0.24*	− 0.12
MMP-7	− 0.16	− 0.18	− 0.2*	− 0.16	− 0.05
MMP9	− 0.11	− 0.14	− 0.18	− 0.04	0.07
CRP	− 0.31**	− 0.32**	− 0.26*	− 0.13	0.15

Numbers represent the correlation coefficient (r), *p < 0.05, **p < 0.01.

CRP C-reactive protein, DLCO diffusion lung capacity for CO, FEV1 forced expired volume in 1 s, FVC forced vital capacity, IGF-1 insulin like growth factor-1, IGFBP-1, -2, -3 insulin-like growth factor -1, -2, -3, IL-8 interleukin-8, KCO the carbon monoxide transfer coefficient, MMP-7, -9 metalloproteinase -7 and -9, TGF-β1 transforming growth factor β, TLC total lung capacity, TNF-α tumor necrosing factor α, YKL-40 chitinase-3-like protein 1.