Table 5.
Association between phenotypes and undergoing primary TKR, with and without adjustment for symptomatic OA and KL grade, after baseline and prior to the 96-month visit (n = 3154). The adjustment refers to adding baseline symptomatic OA and KL grade as additional predictors in the logistic regression model. Both models adjusted for age, sex, and BMI.
| Variable | Number of samples (number of cases underwent TKR in 96 months) | TKR cases Odds ratio (95% CI) |
TKR cases—with adjustment Odds ratio (95% CI) |
|---|---|---|---|
| Phenotypes | |||
| None | 2426(62) | 1[Reference] | 1[Reference] |
| Bone | 531(53) | 4.07 (2.77–5.97)* | 2.11 (1.39–3.19)* |
| Meniscus/cartilage | 75 (7) | 3.73 (1.63 –8.54)* | 0.88 (0.37–2.13) |
| Inflammatory | 38(10) | 13.6 (6.31–29.5)* | 5.69 (2.43–13.4)* |
| Hypertrophy | 84(15) | 6.67 (3.31–12.7)* | 2.65 (1.35–5.19)* |
| Age | 1.02 (1.00–1.04)* | 1.02 (0.98–1.02) | |
| Sex | |||
| Male | 1[Reference] | 1[Reference] | |
| Female | 1.43 (0.99–2.05) | 1.71 (1.16–2.50)* | |
| BMI | 1.03 (0.99–1.07) | 0.99 (0.96–1.03) | |
| Baseline symptomatic OA | – | 1.65 (1.38–2.48)* | |
| Baseline KL grade | |||
| 0–1 | – | 1[Reference] | |
| 2 | – | 5.47 (2.89–10.4)* | |
| 3 | – | 17.6 (9.24–33.6)* | |
| 4 | – | 52.8 (22.9–122)* | |
“-”, not applicable; OA, Osteoarthritis; CI, confidence interval; BMI, body mass index; TKR, total knee replacement; KL, Kellgren-Lawrence.
*Statistically significant at P value < 0.05.