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. 2021 May 25;11:10883. doi: 10.1038/s41598-021-90451-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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ß2 sites are co-targets for the treatment of ALL. (a) Cells were co-treated with ONX-0914 and LU-102 for 1 h, or treated with ONX-0914 for 1 h, followed by 47 h treatment with LU-102, and cell viability was assessed with Alamar Blue (top panels, n = 2–5). Combination indexes were calculated using CalcuSyn software (bottom panels). (b) Top panels, cells were treated with LU-102 for times indicated (left panel) or for 48 h (right panel). Cell viability was assessed with Alamar Blue 48 h after start of the treatments (n = 2). Bottom panel, inhibition of different active sites was measured with fluorogenic substrates in extracts of cells continuously treated with LU-102 (n = 2).