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. 2021 May 25;11:10883. doi: 10.1038/s41598-021-90451-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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ONX-0914 is active in vivo. NSG mice were injected with SEM-GFP-luc cells 10 days prior to the start of subcutaneous treatments with Btz (n = 8), ONX-0914 (n = 8), or vehicle (10 mM sodium citrate, pH 6.0, 10% Captizol; n = 6). The sample size was based on past experience. The control group originally contained 7 animals, but one animal died of an unrelated cause and was not included in the analysis. ONX-0914 and vehicle-treated groups were compared by unpaired t-test; *0.01 < p < 0.05; **p < 0.01. Lines on the left panel connect mean values. A representative image of the animals on d21 is shown at the bottom panel. All other images are presented on Fig. S5.