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. 2021 May 25;12(6):535. doi: 10.1038/s41419-021-03817-2

Fig. 6. Tet2 regulates chromatin accessibility and MyoD binding in the E2 enhancer of MyoG.

Fig. 6

A Pie chart of ATAC-seq analysis. B Methylation and chromatin accessibility profile of the 5′ upstream region of MyoG gene in WT or Tet2 KO myoblasts extracted from the genome-wide methylation-seq and ATAC-seq. The black arrows indicated the major chromatin accessibility peaks absent in Tet2 KO myoblasts. C The H3K4me1 and H3K27ac levels on E2 enhancer of MyoG gene in Tet2 KO myoblasts (n = 3). D Structure of the MyoG enhancer region. E MyoD binding profile in MyoG enhancer region (n = 3). F The level of MyoD recruitment on E2 enhancer in Tet2 KO myoblasts (n = 3). G The distance of CpG sites to E boxes bound by MyoD regardless of methylation status. H The distance of methylated CpG sites to E boxes bound by MyoD. *p < 0.05, **p < 0.01, ***p < 0.001.