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. 2021 May 12;8:662331. doi: 10.3389/fmolb.2021.662331

FIGURE 4.

FIGURE 4

Domains of viral integrases and cofactors. (A) Domains of murine leukemia virus (MLV), prototype foamy virus (PFV) and human immunodeficiency virus (HIV-1) INs. These domains are the N-terminal extension domain (NED), the N-terminal domain (NTD), the catalytic core domain (CCD) and the C-terminal domain (CTD). The numbers along each line represent amino acid residues. (B) Domains of integration host cofactors LEDGF/p75 and Brd4. LEDGF/p75 includes a chromatin binding domain (PWWP) followed by three charged regions (CR1-CR3). Between CR1 and CR2 is a nuclear localization signal (NLS) and two AT-hooks which allow for DNA binding of AT-rich motifs. Near the C-terminus is the integrase binding domain (IBD). Brd4 contains two bromodomains (BD1, BD2) as well as 2 DNA binding motifs, A and B, which in conjunction bind chromatin. There is also a protein interaction extra terminal domain (ET), a serine-rich SEED domain, and a C-terminal motif (CTM).