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Model of LEDGF/p75 tethering an HIV-1 intasome. A mononucleosome (green) wrapped in DNA (black line) representing a nucleosome. The PWWP domain of LEDGF/p75 (cyan) binds the post translational modification H3K36me3. The integrase binding domain (IBD) of LEDGF/p75 is bound to the HIV-1 intasome (red) which is shown as a tetramer for simplicity. The viral DNA genome is shown in black and the dashed lines represent the viral DNA within the intasome.
