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. 2021 May 12;9:612285. doi: 10.3389/fbioe.2021.612285

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Copyright © 2021 Wang, Wu, Lv, Shao, Hungwe, Wang, Bai, Xie, Wang and Geng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathways of sugar metabolism and exopolysaccharides (EPS) biosynthesis in Streptococcus thermophilus (Laws et al., 2001). In Streptococcus thermophilus, exopolysaccharides is synthesized through a series of complex intracellular enzyme interactions. It is exported to the extracellular environment in the form of macromolecules through a special lipid carrier. The biosynthetic pathway of exopolysaccharides includes sugar entry into the cytoplasm, sugar-1-phosphate synthesis, polysaccharide synthesis and exopolysaccharides export. 1: fructokinase; 2: UDP-galactose-4-epimerase; 3: galactokinase; 4: galactose-1-phosphate uridylyltransferase; 5: UDP-glucose pyrophosphorylase; 6: glucokinase; 7: N-acetylglucosamine-1-phosphate uridyltransferase; 8: glucosamine-6-phosphate deaminase; 9: glucose-6-phosphate isomerase; 10: glucosamine-1-phosphate N-acetyltransferase; 11: β-glalactosidase; 12: mannose-6 phosphate isomerase; 13: α-phosphoglucomutase; 14: phosphoglucosamine mutase; 15: phosphomutase; 16: sucrose-6-phosphate hydrolase; 17: dTDP-glucose pyrophosphorylase; 18: UDP-glucose 6-dehydrogenase.