Table 3.
Hormone | Enteroendocrine cell densities (cells/mm2) | Pa-value | Pb-value | Pc-value | Pd-value | Pe-value | Pf-value | Pg-value | Ph-value | Pi-value | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Control, n = 12 | Total IBS,Before, n = 12 | Total IBS,After, n = 12 | PI-IBS, before, n = 6 | PI-IBS, after, n = 6 | Idiopathic IBS, before, n = 6 | Idiopathic IBS, after, n = 6 | ||||||||||
Chromogranin A | 228 ± 33.6 | 370.3 ± 21 | 269.8 ± 22 | 340.8 ± 34 | 422.7 ± 31 | 399.8 ± 20.9 | 316.8 ± 10.2 | 0.0099 | 0.0133 | 0.2 | 0.006 | 0.005 | 0.4 | 0.98 | 0.0006 | 0.0065 |
Secretin | 74 ± 3.8 | 83.8 ± 4.9 | 86.7 ± 5.9 | 80.5 ± 8.8 | 89.7 ± 10.7 | 87.2 ± 4.8 | 83.7 ± 5.9 | 0.32 | 0.21 | 0.99 | 0.5 | 0.1 | 0.3 | 0.5 | 0.099 | 0.6 |
Cholecystokinin | 80 ± 4.7 | 122.8 ± 6.7 | 110.7 ± 8.1 | 113 ± 10.4 | 126.5 ± 0.5 | 132.5 ± 7.2 | 94.8 ± 9 | 0.0007 | 0.023 | 0.055 | 0.005 | 0.0008 | 0.5 | 0.2 | 0.052 | 0.0006 |
Gastric inhibitory peptide | 53.3 ± 5.7 | 65.1 ± 3.8 | 70.3 ± 6.2 | 60 ± 3 ± 3.7 | 84 ± 7.1 | 69.8 ± 6.3 | 57.2 ± 7 | 0.33 | 0.19 | 0.96 | 0.01 | 0.2 | 0.99 | 0.5 | 0.014 | 0.2 |
Serotonin | 76.5 ± 13.6 | 135.1 ± 14.7 | 142 ± 12.8 | 100.5 ± 7.1 | 160.7 ± 16.6 | 169.7 ± 20.6 | 123.3 ± 17.3 | 0.04 | 0.0088 | 0.7 | 0.005 | 0.01 | 0.2 | 0.7 | 0.012 | 0.034 |
Somatostatin | 42.3 ± 5.6 | 58.6 ± 4 | 66.2 ± 6.3 | 52.3 ± 2.7 | 78.5 ± 8.1 | 64.8 ± 7 | 53.8 ± 6.8 | 0.033 | 0.012 | 0.3 | 0.006 | 0.03 | 0.3 | 0.3 | 0.011 | 0.017 |
Data are presented as the mean ± SEM. Comparison: Kruskal–Wallis with Dunn’s post test, acontrols vs. total IBS patients before FMT, bcontrols vs. total IBS patients after FMT, ccontrols vs. PI IBS patients before FMT, dcontrols vs. PI IBS patients after FMT, econtrols vs. idiopathic IBS patients before FMT, fcontrols vs. idiopathic IBS patients after FMT; and Paired t test, gtotal IBS patients before vs. after FMT, hPI-IBS patients before vs. after FMT, IIdiopathic IBS patients before vs. after FMT. FMT, fecal microbiota transplantation; IBS, irritable bowel syndrome; PI, post-infectious.
The bolded numbers are significant values <0.05.