TABLE 3.
Gabapentin dose regimens in reported pediatric oncology studies
| Reference | Study design (No. of patients) | Patient population | Gabapentin regimen (daily)* | Concurrent pain medications |
|---|---|---|---|---|
| Anghelescu 201725 | Prospective (n=30) | Children with neuropathic pain after limb sparing or amputation for osteosarcoma | Initial dose (mean): 20.2 mg/kg Maximum dose: 43.8 mg/kg |
Amitriptyline (n=5), methadone (n=4) |
| Anghelescu 201111 | Retrospective (n=153) | Patients with childhood ALL and VCR-related neuropathic pain | Initial dose (mean): 14.2 mg/kg | Concurrent medications not evaluated |
| Butkovic 200613 | Case series (n=1) | 18-year-old with neuropathic pain related to metastatic osteosarcoma | Initial dose: 10, 20, or 30 mg/kg Maintenance dose:10 mg/kg for 2–4 weeks at maximum dose |
Morphine, methadone, fentanyl patch, amitriptyline, anti-inflammatory |
| Butkovic 200613 | Case series (n=1) | 17-year-old with pelvic Ewing sarcoma–related neuropathic pain | Initial dose: 30 mg/kg for 3 weeks Maintenance dose: 10 mg/kg |
Tramadol, fentanyl PCA, fentanyl patch, amitriptyline, anti-inflammatory |
| Butkovic 200613 | Case series (n=1) | 14-year-old with metastatic ovarian carcinoma–related neuropathic pain | Dose titrated up to 30 mg/kg for 2 weeks Maintenance dose: 15 mg/kg |
Fentanyl patch, amitriptyline, anti-inflammatory |
| Butkovic 200613 | Case series (n=1) | 15-year-old with osteosarcoma-related neuropathic pain | Dose titrated up to 25 mg/kg for 2 weeks Maintenance dose: 20 mg/kg |
Tramadol, acetaminophen |
| Keskinbora 200420 | Case report (n=1) | 12-year-old with Ewing sarcoma–related neuropathic pain | Initial dose increased daily: 100 mg (~2.9 mg/kg)**, 100 mg BID (~5.7 mg/kg)**, 100 mg TID (~8.6 mg/kg)** Maintenance dose: 300 mg TID (~25.7 mg/kg)** |
|
| Madden 201723 | Case series (n=1) | 19-year-old with ALL and VCR-related neuropathic pain | 45 mg/kg per day | Methadone, amitriptyline |
| Madden 201723 | Case report (n=1) | 6-year-old with ALL and VCR-related neuropathic pain | 45 mg/kg per day | Methadone, morphine |
Abbreviations: BID, twice per day; PCA, patient-controlled analgesia; TID three times per day
*
Doses in mg/kg per day unless otherwise specified;
**
Values estimated based on weight