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. 2021 May 12;12:675385. doi: 10.3389/fendo.2021.675385

Figure 2.

Figure 2

From the perspective of energy metabolism, abnormal osteoclast proliferation, senescence, apoptosis and autophagy phenotypes lead to osteoporosis. The imbalance in homeostasis between osteoclast survival and the bone resorptive capacity is a key factor contributing to the development of osteoporosis. ATP, adenosine triphosphate; mtDNA, mitochondrial DNA. –, negative control; +, positive control.