Figure 2.
From the perspective of energy metabolism, abnormal osteoclast proliferation, senescence, apoptosis and autophagy phenotypes lead to osteoporosis. The imbalance in homeostasis between osteoclast survival and the bone resorptive capacity is a key factor contributing to the development of osteoporosis. ATP, adenosine triphosphate; mtDNA, mitochondrial DNA. –, negative control; +, positive control.