TABLE 2.
Hubs in the PPI network.
| Gene symbol | Full name | Degree |
| DLD | Dihydrolipoamide Dehydrogenase | 19 |
| ACLY | ATP Citrate Lyase | 13 |
| CAT | Catalase | 13 |
| ACADM | Acyl-CoA Dehydrogenase Medium Chain | 12 |
| HADH | Hydroxyacyl-CoA Dehydrogenase | 12 |
| MRPL46 | Mitochondrial Ribosomal Protein L46 | 12 |
| MRPL53 | Mitochondrial Ribosomal Protein L53 | 11 |
| MRPL1 | Mitochondrial Ribosomal Protein L1 | 11 |
| MRPL40 | Mitochondrial Ribosomal Protein L40 | 11 |
| MRPS16 | Mitochondrial Ribosomal Protein S16 | 11 |
| ACAT1 | Acetyl-CoA Acetyltransferase 1 | 11 |
| RPLP0 | Ribosomal Protein Lateral Stalk Subunit P0 | 11 |
| OXA1L | OXA1L Mitochondrial Inner Membrane Protein | 11 |
DLD, patients with point mutations (p.D479V and p.R482G) at the DLD homodimer interface were affected with HCM (Shany et al., 1999; Odievre et al., 2005). CAT, JMJD1A (Jumonji domain containing 1A) represses the development of cardiomyocyte hypertrophy by upregulating the expression of CAT (Zang et al., 2020). ACLY, ACLY was associated with TAC (thoracic aortic constriction) induced cardiac hypertrophy by regulating autophagy (Marino et al., 2014).