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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Curr Opin Struct Biol. 2021 Feb 2;67:219–225. doi: 10.1016/j.sbi.2020.12.012

Figure 2.

Figure 2.

Relating single chain properties to phase separation. (A) Internal distance scaling for a single protein chain yields an effective scaling exponent ν as a function of temperature (B) – Tθ is the temperature at which v = 1/2. (C) Slab simulations (shown as insets) as a function of temperature establish the one-phase and two-phase regions of the phase diagram and an estimate of the critical temperature Tc. (D) Tc is remarkably well correlated with Tθ for a range of different sequences [51].