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. 2020 Nov 23;37(8):1039–1044. doi: 10.1093/bioinformatics/btaa920

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© The Author(s) 2020. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2. — Genomic distribution of RERs. (a) Pie chart showing the distribution of RERs across gene features (within a ±1 kb window around TSSs, introns and intergenic regions). (b) Pie chart showing the classification of RERs as promoters or enhancers. (c) Top, Average profile of RERs found within ±1 kb around TSSs [the confidence interval was estimated by the bootstrap method (resample = 1000)]. Bottom, Heatmap of RERs found within ±1 kb around annotated gene TSSs. (d) Proportion histogram showing peaks located within ±1 kb around TSSs, with each bar representing one stage (P-value < 2.2e-14, Chi-square test)