Table 1.
Transethnic meta-analysis estimated main and interaction effects (β a) and SE for rs16969968, age of smoking initiation, and their interaction
| AOS | rs16969968_A | rs16969968 × AOS | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CPD coding | N | AOS coding | β | SE | p | β | SE | p | β | SE | p | Direction | HetChiSq | HetPVal |
| CPD (raw) | 128 383 | Raw | −0.296 | 1.15e-02 | 9.34e-147 | 1.271 | 2.17e-01 | 4.65e-09 | −0.019 | 1.24e-02 | 1.17e-01 | -++++--+-+- | 5.299 | 8.70e-01 |
| Binned | −0.830 | 3.59e-02 | 3.89e-118 | 1.042 | 6.53e-02 | 2.57e-57 | −0.063 | 3.81e-02 | 1.01e-01 | -++++--+-+- | 3.059 | 9.80e-01 | ||
| Early/late | 1.589 | 8.18e-02 | 4.99e-84 | 0.861 | 5.97e-02 | 3.41e-47 | 0.190 | 8.71e-02 | 2.87e-02* | +-+---+-+++ | 4.433 | 9.26e-01 | ||
| Log10(CPD) | 128 383 | Raw | −0.008 | 2.88e-04 | 6.91e-159 | 0.026 | 5.36e-03 | 1.55e-06 | 0.000 | 3.07e-04 | 7.86e-01 | -+++---+++- | 4.023 | 9.46e-01 |
| Binned | −0.021 | 8.83e-04 | 1.80e-129 | 0.025 | 1.60e-03 | 4.22e-54 | 0.000 | 9.34e-04 | 8.19e-01 | -++-+-++-+- | 3.02 | 9.81e-01 | ||
| Early/late | 0.040 | 2.01e-03 | 1.95e-86 | 0.023 | 1.46e-03 | 3.40e-56 | 0.003 | 2.13e-03 | 2.12e-01 | +--------++ | 4.396 | 9.28e-01 | ||
| Binned | 128 383 | Raw | −0.023 | 9.39e-04 | 1.10e-130 | 0.102 | 1.77e-02 | 9.89e-09 | −0.001 | 1.01e-03 | 2.03e-01 | -+++---+++- | 4.992 | 8.92e-01 |
| Binned | −0.065 | 2.93e-03 | 3.07e-109 | 0.089 | 5.32e-03 | 4.94e-63 | −0.006 | 3.11e-03 | 6.59e-02 | -++++--+-+- | 5.804 | 8.31e-01 | ||
| Early/late | 0.126 | 6.67e-03 | 2.55e-79 | 0.074 | 4.87e-03 | 1.26e-52 | 0.015 | 7.10e-03 | 3.79e-02* | +++---+--++ | 4.273 | 9.34e-01 | ||
| Heavy/light | 61 077 | Raw | −0.018 | 1.41e-03 | 1.15e-38 | 0.116 | 3.94e-02 | 3.16e-03 | 0.000 | 2.16e-03 | 9.00e-01 | -++----+-+- | 7.649 | 6.63e-01 |
| Binned | −0.077 | 4.92e-03 | 1.23e-54 | 0.146 | 1.27e-02 | 2.78e-30 | −0.001 | 6.80e-03 | 8.30e-01 | -+--+-++-+- | 7.851 | 6.43e-01 | ||
| Early/late | 0.171 | 1.21e-02 | 3.65e-45 | 0.116 | 1.05e-02 | 4.82e-28 | 0.004 | 1.62e-02 | 8.22e-01 | +++---+---+ | 4.666 | 9.12e-01 | ||
| Heavy/light (additive scale) | 61 077 | Raw | −0.013 | 7.19e-04 | 6.59e-76 | 0.094 | 1.43e-02 | 5.02e-11 | −0.002 | 8.15e-04 | 2.87e-02* | -++----+-+- | 8.097 | 6.19e-01 |
| Binned | −0.044 | 2.23e-03 | 2.40e-88 | 0.070 | 4.24e-03 | 2.40e-61 | −0.005 | 2.45e-03 | 5.70e-02 | -+--+-++-+- | 8.095 | 6.20e-01 | ||
| Early/late | 0.090 | 5.17e-03 | 4.34e-67 | 0.058 | 3.88e-03 | 7.84e-50 | 0.012 | 5.69e-03 | 3.41e-02* | +++---+---+ | 4.745 | 9.08e-01 | ||
Cochran’s Q-test of heterogeneity as estimated in METAL is shown for the interaction effect. Shown are estimates for each encoding of CPD and AOS. AOS = age of smoking initiation; CPD = cigarettes per day.
aβ refers to the regression slope. For CPD coded as heavy/light, exp(β) is the odds ratio when analyzed on the multiplicative scale.
*p < .05.