FIGURE 1.

Total Glucocorticoid Metabolites, 11β‐hydroxysteroid dehydrogenase type 1 and 5α‐reductase activities based on urinary multi‐steroid profiling by GC‐MS. Statistical analysis performed on log‐transformed steroid values or ratios. Data shown: mean ± SD. Two and 4 data points not shown in (A) and (B), respectively, for graphical purposes. Both 11β‐hydroxysteroid dehydrogenase type 1 (A) and 5α‐reductase (B) activities are increased in patients with NAFLD with advanced fibrosis, although not in those with mild disease when compared with controls. Total glucocorticoid metabolite production was not different across the spectrum of NAFLD or in comparison with controls (****P < 0.0001, *P < 0.05). NAFLD, non‐alcoholic fatty liver disease