TABLE 3.
GMLVQ analysis identifies the 10 most discriminatory steroid metabolites for distinguishing clinically relevant stages of NAFLD
| Discriminatory ranking | NAFLD stage comparison | |||
|---|---|---|---|---|
| F0‐2 vs F3‐4 | F0‐3 vs F4 | Control vs F3‐4 | Control vs F4 | |
| 1 | Etiocholanolone | Etiocholanolone | 5α‐tetrahydro‐11‐dehydrocorticosterone | 5α‐tetrahydro‐11‐dehydrocorticosterone |
| 2 | Dehydroepiandrosterone | Tetrahydrocorticosterone | 11‐oxoetiocholanolone | 11‐oxoetiocholanolone |
| 3 | 5α‐tetrahydro‐11‐dehydrocorticosterone | 5α‐tetrahydro‐11‐dehydrocorticosterone | Etiocholanolone | Etiocholanolone |
| 4 | Androstendione | Tetrahydro‐11 deoxycorticosterone | Cortisone | Cortisone |
| 5 | 5α‐tetrahydrocorticosterone | Dehydroepiandrosterone | Pregnenediol | Tetrahydro‐11 deoxycorticosterone |
| 6 | Pregnenetriol | Androsterone | Pregnanetriol | Pregnenediol |
| 7 | Tetrahydro‐11 deoxycorticosterone | Tetrahydrocortisone | Tetrahydro‐11 deoxycorticosterone | Pregnanetriol |
| 8 | Tetrahydroaldosterone | Tetrahydrocortisol | 11β‐hydroxyetiocholanolone | Tetrahydrocorticosterone |
| 9 | Cortisone | Pregnenetriol | Pregnanediol | Pregnanediol |
| 10 | 11‐oxoetiocholanolone | 5α‐tetrahydrocorticosterone | 5α‐tetrahydrocorticosterone | 5α‐tetrahydrocorticosterone |
Abbreviations: GMLVQ, Generalised Matrix Learning Vector Quantisation; NAFLD, non‐alcoholic fatty liver disease.