Fig. 3.

Intraneuronal aluminum in the temporal cortex of a 57-year-old female Colombian donor with familial Alzheimer’s disease. A) Intracellular aluminum (Al) in a neuron (orange). B) AT8 immunoreactive phosphorylated tau (pTau) located via DAB staining (brown). C). Autofluorescence (green) of the non-stained adjacent section highlighting occasional deposits of intracellular lipofuscin (yellow). D) Merging of lumogallion and brightfield channels depicting aluminum and pTau in the identical neuron. Asterisks denote magnified inserts. Magnification: X 400, scale bars: 50μm.