PARP	Poly (adenosine diphosphate-ribose) polymerase	NHEJ	Nonhomologous end joining
PARPis	Poly (adenosine diphosphate-ribose) polymerase inhibitors	DSB	Double-stranded break
HRR	Homologous Recombination Repair	C-NHEJ	Classical non-homologous terminal connections
PC	Prostate Cancer	Alt-EJ	Alternative terminal connections
FDA	Food and Drug Administration	SSA	Single-strand annealing
mCRPC	Metastatic castration resistant prostate cancer	SSB	Single strand break
ADT	Androgen deprivation therapy	PSA	Prostate-specific antigen
AR	Androgen receptor	CTC	circulating tumor cell
CRPC	Castration-resistant prostate cancer	NGS	Next-generation sequencing
DDR	DNA damage repair	rPFS	radiographic progression-free survival
USP7	Ubiquitin-specific protease 7	NHA	New hormone therapy
BET	Bromodomain and extra terminal domain	ORR	Objective response rate
ATM	Ataxia telangiectasia mutated	EMSO	European Society for Medical Oncology
ATR	Ataxia- and Rad-related	ASCO	American Society of Clinical Oncology
CHEK1/2	Checkpoint kinase1/2	SSB	single strand break
FEN1	Flap endonuclease-1	MMR	mistake match repair
TCGA	The Cancer Genome Atlas	HRR	homologous recombination repair
mPC	Metastatic prostate cancer	OR	objective response
ADPRT1	ADP ribozyme transferase-1 gene	DRD	DNA-repair gene defects
BER	Base excision repair	NER	Nucleotide excision repair