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. 2021 May 11;10(5):1161. doi: 10.3390/cells10051161

Figure 4.

Figure 4

BBR increased the cerebral cortical blood flow perfusion and increased proangiogenic factors in the brains of 3×Tg AD mice. (A) Representative images of cerebral cortical blood flow perfusion in three groups. (B) Analysis of the level of cerebral cortical blood flow perfusion in three groups. (C) Immunofluorescence of CD31 (green) in the hippocampi of mice from the three groups. Scale bar: 20 μm. (D) Quantification of CD31 immunoreactivity in the hippocampi of mice. (E) Western blotting showed protein level of CD31, VEGF, N-Cadherin and Ang-1 in three groups. (F) Analysis of protein level of CD31, VEGF, N-Cadherin and Ang-1. WT, wild-type mice; 3×Tg, 3×Tg AD mice; BBR + 3×Tg; 3×Tg AD mice were given BBR at 100 mg/kg/day. One-way ANOVA and Dunnett’s post-hoc test were used to analyze all the data, which are presented as mean ± SD; n = 12 animals/group. * p < 0.05, ** p < 0.01.