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NSCs are functionally heterogeneous in the adult DG. (A) Ascl1-labeled NSCs undergo several asymmetric divisions before all cells differentiate into NPCs for the subsequent production of new neurons. (B) Gli1-labeled NSCs can undergo symmetric division first and then repeat asymmetric division with a slower cycle than Ascl1-labeled NSCs. This population conceivably contributes to the preservation of the NSC pool in the adult DG.
