Table 2.

Levodopa kinetic-dynamic variables by patients’ subgroups

	Patients’ subgroups
Levodopa kinetic-dynamic variables	Possible PD	Probable PD	AP
Test dose (mg/kg)	1.4±0.3	1.4±0.3	1.5±0.3
tmax (min)	30 (30–60)	30 (30–45)	30 (30–45)
Cmax (mg/L)	2.0±0.8	2.1±0.8	1.9±0.7
Tap0 (tap/min)*	134±34	137±37	88±34
Tapmax(tap/min)*	179±45	187±49	112±50
ETapmax (tap/min)*	42 (29–59)	43 (32–63)	21 (13–33)
DeltaTapmax%	30 (24–39)	30 (22–41)	23 (19–33)
AUC_ETap* [(tap/min)×min]	5385 (3300–7410)	5925 (3982–8261)	1799 (442–4100)

Data are expressed as mean±standard deviation or median (25-75th percentiles).PD, Parkinson’s disease; AP, Atypical parkinsonism; mg, milligram; kg, kilogram; L, liter; tmax, time to levodopa (LD) peak; Cmax, LD peak plasma concentration; Tap0, tapping frequency at baseline; Tapmax, maximum tapping frequency after LD dose; ETapmax, difference between Tapmax and Tap0; DeltaTapmax%, ETapmax over baseline values expressed as percentage; AUC_ETap, area under the 3 h tapping effect-time curve.^*p < 0.001, AP versus Possible and Probable PD.