Table 1.
Pre | Day 1b | Day 1a | Day 4 | Day 8 | Day 15 | ||
---|---|---|---|---|---|---|---|
2nd Derivative Peak Time (sec) | PRP | 51.8 (48.3-56.1) | 56.1 (49.9-60.6) | 76.9 (67.3-83.2)b | 73.6 (68.6-84.0)b | 77.5 (65.2-90.2)b | 63.9 (57.7-69.7)b |
P | <0.01 | NS | <0.01 | <0.01 | <0.01 | <0.01 | |
PPP | 58.6 (50.8-66.3) | 58.7 (49.3-67.4) | 88.5 (72.8-103.6)b | 89.3 (78.4-100.1)b | 95.5 (77.2-107.6)b | 73.4 (62.3-83.0)b | |
2nd Derivative Peak Height (mm Absorbance) | PRP | 114 (90.9-152) | 135 (104-176) | 104 (79.9-131) | 163 (111-211)b | 133 (94.2-161) | 148 (99.8-184) |
P | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | |
PPP | 44.0 (34.0-62.4) | 58.2 (48.4-77.8)c | 35.9 (26.7-43.7)c | 49.4 (36.6-67.6) | 114 (94.9-167) | 107 (96.8-145) | |
1st Derivative Peak Time (sec) | PRP | 62.9 (58.7-68.6) | 65.4 (60.6-73.8) | 88.2 (77.8-96.3)b | 87.0 (81.5-107)b | 94.1 (78.5-103)b | 77.9 (69.6-84.3)b |
P | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | |
PPP | 81.7 (72.7-92.5) | 81.1 (70.4-91.1) | 124 (104-138)b | 125 (111-143)b | 127 (104-144)b | 102 (91.1-112)b | |
1st Derivative Peak Height (mm Absorbance) | PRP | 143 (115-172) | 185 (144-203)c | 185 (158-228)b | 309 (256-367)b | 241 (200-283)b | 196 (164-225)b |
P | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | |
PPP | 84.4 (68.7-100) | 113 (99.3-127)b | 107 (90.2-115)b | 154 (118-198)b | 121 (100-143)b | 118 (102-130)b | |
Fibrin Formation Time (sec) | PRP | 61.3 (58.3-68.6) | 66.1 (60.6-74.5)d | 89.3 (78.6-96.0)b | 88.0 (82.1-102)b | 91.9 (78.7-99.2)b | 77.1 (68.5-82.4)b |
P | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | |
PPP | 87.1 (76.1-96.1) | 85.8 (75.7-95.3) | 131 (112-146)b | 136 (117-154)b | 135 (112-153)b | 109 (96.2-116)b | |
Fibrin Formation Height (mm Absorbance) | PRP | 339 (300-378) | 345 (297-369) | 418 (376-462)b | 675 (608-739)b | 578 (502-636)b | 501 (451-580)b |
P | <0.001 | <0.05 | NS | NS | NS | <0.001 | |
PPP | 250 (225-296) | 312 (264-345)b | 411 (381-480)b | 665 (620-722)b | 552 (473-613)b | 407 (343-494)b |
Abbreviations: sTF/FIX, small tissue factor induced FIX activation; PRP, platelet-rich plasma; PPP, platelet-poor plasma; NS, not significant.
a P values indicate the difference between PRP and PPP.
b P < 0.001 in comparison with “pre.”
c P < 0.01 in comparison with “pre.”
d P < 0.05 in comparison with “pre.”