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Key genetic aberrations of somatic hypermutation subgroups in diffuse large B-cell lymphoma (DLBCL), identified by Alkodsi et al.46.
| Subgroup | Key genetic features |
|---|---|
| SHM1 | EZH2, KMT2D, CREBBP, MYC, BCL2, GNA13, GNA12, P2RY8, Chr7, Chr8 gains |
| SHM2 | MYD88, CD79B, CDKN2A, PIM1, MPEG1, ETV6, IRF4, Chr3, Chr18 gains |
| SHM3 | SOCS1, STAT3, STAT6, TNFAIP3, SGK1, IRF8, Chr3, Chr7 Chr18 gains |
| SHM4 | BCL6, CD70, BCL10, SPEN, MYD88 (not L265P), HLA-A,B,C |
Chr, Chromosome.
