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. 2021 May 21;49(5):03000605211009722. doi: 10.1177/03000605211009722

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© The Author(s) 2021

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — In 162 paired specimens, agrin was significantly overexpressed in CCA tissues compared with its levels adjacent non-CCA tissues according to RT-PCR (a). Furthermore, additional overexpression of agrin was correlated with increases of mortality rates (b), PVTT (c) tumor size (d), and tumor number (e). Immunohistochemistry also revealed that agrin protein expression was significantly higher in CCA tissues than in normal tissues (f–g)

CCA, cholangiocarcinoma; PVTT, portal vein tumor thrombus.