Fig. 7.

Progressive neuroinflammation in Tg4-42 +/+ mice. Immunoreactive (IR) area in percent of GFAP expression levels labeling reactive astrocytes in the cortex (a), caudate putamen (b), hippocampus (c), and Iba-1 expression levels labeling activated microglia in the cortex (d), caudate putamen (e), and hippocampus (f). a-f) n = 7 per group. Mean + SEM. Two-way ANOVA followed by Bonferroni’s post hoc test. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001. g) Representative images of GFAP and Iba-1 labeling of caudate putamen samples in 9-month-old Tg4-42 +/+ and non-transgenic mice (NTG).