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. 2021 May 11;12:671902. doi: 10.3389/fphar.2021.671902

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Copyright © 2021 Long, Qiu, Zhang, He, Shi, He, Chen, Shen, Li and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional 13N-ammonia PET/CT imaging of PC3 xenografts in vivo shows a significant reduction in 13N-ammonia uptake under VC treatment. (A) Tumor 13N-ammonia uptake in treated and control mice. 13N-ammonia PET/CT were conducted before (day 0) and 3 days after therapy initiation. Right panels, representative PET/CT scans showing change of tumor tracer uptake (red arrows). (B) Tumor-to-background ratio (TBR) was calculated and served as an indicator of tracer uptake. Mean TBR of 13N-ammonia PET/CT was reduced in VC treated mice compared to controls. Immunohistochemical analyses showed the expression of GS decreased in the VC treatment specimens. All data are presented as means ± SEM, *p < 0.05, n = 3. VC, Vitamin C; GS, glutamine synthetase.