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Mechanism for the reduced phosphorylated α-syn pathology in immunocompromised mice that received adoptive transfer of T cells. PFFs activate resting microglia to become active and phagocytose PFFs. The presence of T cells releasing IFN-γ helps to further activate microglia and enhance phagocytosis. This results in less pathology and neuronal survival. Schematic created with BioRender.com.
