Figure 7.

Therapeutic targets in the spliceosome and inhibitors of the mRNA splicing reaction. Main figure: structural components of the spliceosome needed for the mRNA splicing reaction; insert: splicing factors that regulate splice site usage. Identified targets in the spliceosome are shown in red. Main representative molecules and classes of splicing inhibitors are shown, with an indication of their interference with the process. For several inhibitors, the target protein is known; for others only the spliceosome complex that is inhibited, or the complex transition step that is prevented. In cases where there is doubt about the step that is inhibited, the compound is shown at multiple steps and marked with an asterisk.