. 2021 May 25;4(5):e2111398. doi: 10.1001/jamanetworkopen.2021.11398

Table 3. Serum Testosterone Concentration in Men by ICU Admission, Ventilator Use, and Mortality^a.

Patient group	Concentration, median (IQR)
Patient group	Day 0	Day 3	Day 7	Day 14	Day 28
With ICU admission (n = 53)	49 (17-109)^b	17 (5-42)^c	20 (12-56)^d	29 (9-90)	27 (24-84)
Without ICU admission (n = 37)	142 (83-221)	104 (49-166)	136 (58-229)	152 (83-221)	230 (215-466)^e
With ventilator use (n = 24)	38 (10-84)^f	12 (1-19)^g	18 (1-35)^h	15 (7-55)ⁱ	26 (22-48)^j
Without ventilator use (n = 66)	104 (49-205)	60 (26-134)	88 (19-195)	93 (81-131)	228 (182-466)^k
Died (n = 25)	42 (15-76)^l	15 (1-32)^m	18 (13-20)	15 (3-45)	NA
Survived (n = 65)	108 (49-203)	49 (14-119)ⁿ	55 (13-155)	61 (10-110)	135 (26-229)

Abbreviations: ICU, intensive care unit; IQR, interquartile range; NA, not applicable (indicated if there were insufficient patients in a category).

SI conversion factor: To convert testosterone to nanomoles per liter, multiply by 0.0347.

^{^a}

Comparator group included men with no ICU stay, with no ventilator use, or who survived. Comparison adjusted for group differences in age, body mass index, Charlson Comorbidity Index score, smoking history, and race.

^{^b}

P < .001 for comparator group.

^{^c}

P = .006 for comparator group; P =.003 compared with day 0.

^{^d}

P = .04 for comparator group.

^{^e}

P = .04 compared with day 0.

^{^f}

P < .001 for comparator group.

^{^g}

P < .001 for comparator group; P = .001 compared with day 0.

^{^h}

P = .001 for comparator group.

^ⁱ

P = .01 for comparator group.

^{^j}

P = .004 for comparator group.

^{^k}

P = .007 compared with day 0.

^{^l}

P = .007 for comparator group.

^{^m}

P = .002 for comparator group; P = 0.03 compared with day 0.

^ⁿ

P = .01 compared with day 0.

Table 3. Serum Testosterone Concentration in Men by ICU Admission, Ventilator Use, and Mortalitya.

Table 3. Serum Testosterone Concentration in Men by ICU Admission, Ventilator Use, and Mortality^a.