Fig. 1.

Flow Diagram of Exclusion Criteria. “Pure” Lewy body disease pathology (LBD) groups exhibited low Alzheimer’s disease neuropathologic change (ADNC). Low ADNC includes Neuritic plaque score (CERAD[26]) equivalent to C0 or C1, and Braak Neurofibrillary Tangle Score (Braak Stage; equivalent to B0 or B1 [27]). LBD groups were further delineated into brainstem (LBD-b; most commonly observed in the substantia nigra or locus coeruleus), limbic (LBD-l; cingulate, entorhinal, amygdala), and cerebral cortical (LBD-c) groups. Combined pathology groups (ADNC/LBD) exhibited intermediate or high ADNC and the presence of Lewy body neuropathology and were further delineated into brainstem (ADNC/LBD-b), limbic (ADNC/LBD-l), and cerebral cortical (ADNC/LBD-c) groups. “Pure” ADNC exhibited intermediate or high ADNC and no LBD. Healthy controls (HC) exhibited low ADNC and no LBD and no diagnosis of dementia at any evaluation. NACC, National Alzheimer’s Coordinating Center; UDS, Uniform Data Set; FTD, frontotemporal dementia; CERAD, Consortium to Establish a Registry for Alzheimer’s disease criteria.