Table 2.
Correlations of Aβ42, T-tau, P-tau, NFL, and NRGN in lumbar- and intraventricular-CSF
| Aβ42 | T-tau | P-tau | NFL | NRGN | |
| Lumbar CSF | |||||
| Aβ42 | 1 | *–0.23 | –0.10 | *–0.21 | *–0.19 |
| T-tau | *–0.23 | 1 | ***0.88 | **0.31 | ***0.60 |
| P-tau | –0.10 | ***0.88 | 1 | *0.25 | ***0.55 |
| NFL | *–0.21 | **0.31 | *0.25 | 1 | *0.17 |
| NRGN | *–0.19 | ***0.60 | ***0.55 | *0.17 | 1 |
| Intraventricular | |||||
| Aβ42 | 1 | 0.01 | *0.19 | –0.05 | 0.07 |
| T-tau | 0.01 | 1 | ***0.78 | *0.24 | ***0.43 |
| P-tau | *0.19 | ***0.78 | 1 | 0.16 | ***0.44 |
| NFL | –0.05 | *0.24 | 0.16 | 1 | 0.06 |
| NRGN | 0.07 | ***0.43 | ***0.44 | 0.06 | 1 |
| L-CSF &V-CSF | ***0.87 | ***0.83 | ***0.92 | ***0.94 | ***0.90 |
Significances of Pearson-r values presented as *p < 0.05, **p < 0.001, ***p < 0.0001. Aβ42, Amyloid-β 42 protein; T-tau, total tau; P-tau, tau phosphorylated at threonine 181; NFL, neurofilament light; NRGN, neurogranin; L-CSF, cerebrospinal fluid collected with lumbar puncture; V-CSF, cerebrospinal fluid collected with shunt valve puncture.