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. 2021 May 9;13(5):679. doi: 10.3390/pharmaceutics13050679

Table 2.

Modified Ashcroft scale for histological grading of lung damage.

Grade of Fibrosis Modified Scale
0 Alveolar Septa: No fibrotic burden at the flimsiest small fibers in some alveolar walls
Lung structure: Normal lung
1 Alveolar Septa: Isolated gentle fibrotic changes (septum ≤3× thicker than normal)
Lung structure: Alveoli partly enlarged and rarefied, but no fibrotic masses present.
2 Alveolar Septa: Clearly fibrotic changes (septum >3× thicker than normal) with not-like formation but not connected to each other
Lung structure: Alveoli partly enlarged and rarefied, but no fibrotic masses.
3 Alveolar Septa: Contiguous fibrotic walls (septum >3× thicker than normal) predominantly in whole microscopic field
Lung structure: Alveoli partly enlarged and rarefied, but no fibrotic masses.
4 Alveolar Septa: Variable
Lung structure: Single fibrotic masses (≤10% microscopic field)
5 Alveolar Septa: Variable
Lung structure: Confluent fibrotic masses (>10% and ≤50% of microscopic field). Lung structure severely damaged but still preserved.
6 Alveolar Septa: Variable, most not existent
Lung structure: Large contiguous fibrotic masses (>50% of microscopic field). Lung architecture mostly not preserved.
7 Alveolar Septa: Non-existent
Lung structure: Alveoli nearly obliterated with fibrous masses but still up to five air bubbles.
8 Alveolar Septa: Non-existent
Lung structure: Microscopic field with complete obliteration with fibrotic masses.