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. 2021 May 10;11(5):706. doi: 10.3390/biom11050706

Figure 3.

Figure 3

The binding affinity and model of azelnidipine to SIRPα and PVR. Binding of azelnidipine to human and mouse SIRPα or PVR was examined by the MST. (A,B) Dose response curves of azelnidipine binding to human SIRPα (A) and PVR (B). (C,D) Dose response curves of azelnidipine binding to mouse SIRPα (C) and PVR (D). The KD values were calculated with analysis software (MO. Affinity Analysis v2.2.4). Data are representative of at least three independent experiments. (E) The binding model and detail of azelnidipine to SIRPα. The protein surface of CD47 (magenta) and SIRPα (blue) and azelnidipine (yellow) are shown, with the interactions labeled. (F) The binding model and detail of azelnidipine to PVR. The protein surfaces of TIGIT (magenta) and PVR (blue) and azelnidipine (yellow) are shown, with the interactions labeled.