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. 2021 May 10;10(5):1147. doi: 10.3390/cells10051147

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Over-expression of Skp2 contributes to cisplatin resistance and radiation resistance by enhanced MDR expression, DNA damage repair and EMT property. Black arrows indicate signaling pathways. P: phosphorylation; Ac: Acetylation; De-Ac: Deacetylation; Me: Methylation; Ub, Ubiquitination. MDR1: multi-drug resistance protein 1, MRP1: multi-drug resistance associated protein, FAM60A: family with sequence similarity 60A, USP10: ubiquitin specific peptidase 10, SIRT: sirtuin, MRN: Mre11-Rad50-Nbs1, CHK1: checkpoint kinase 1, G9A: euchromatic histone lysine methyltransferase 2, FOXO: forkhead box O, YAP: yes-associated protein, ATM: ataxia-telangiectasia mutated gene, TWIST: twist family bHLH transcription factor, β-TrCP: beta-transducin repeats-containing proteins, EMT: Epithelial-Mesenchymal Transition.