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. 2021 May 12;8(5):22. doi: 10.3390/medicines8050022

Figure 3.

Figure 3

Influence of quercetin on the appearance of angiogenic factors in nasal lavage fluids obtained from OVA-sensitized mice after nasal antigenic provocation. OVA-sensitized mice were treated orally with various doses of quercetin once a day for five days before OVA nasal provocation. Nasal lavage fluids were obtained from the mice 6 h after nasal antigenic provocation. The concentration of VEGF (A), bFGF (B), TNF (C), IL-6 (D) and IL-8 (E) were examined by ELISA. The data are expressed as the mean pg/ng IgA ± SE of five mice. OVA: ovalbumin; VEGF: vascular endothelial growth factor; bFGF: basic fibroblast growth factor; TNF: tumor necrosis factor-α; Nor. Cont.: normal control; IS: intraperitoneal sensitization alone; NC: nasal challenge alone; and N.S.: not significant (p > 0.05) vs. IS + NC, quercetin (0 mg/kg). * Significant (p < 0.05) vs. Nor. C.; ** Significant (p < 0.05) vs. IS + NC, quercetin (0 mg/kg).