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. 2021 May 11;11(5):301. doi: 10.3390/metabo11050301

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Plasma FGF21 concentration. FGF21, fibroblast growth factor 21. Con, LPHF, and HPHF represent chow diet, low-protein high-fat diet, and high-protein high-fat diet, respectively. Sed, sedentary behavior; T, training. Feed, training, and interaction indicate a dominant effect of diet, treadmill exercise, and the interactive effect between feed and training, respectively. n.s., no significance was observed. * p < 0.05 and *** p < 0.001. @, p < 0.05; &, p < 0.01; #, p < 0.001. Data are presented as the mean ± SD. n = 8 for each group. Significance in the differences between means was determined by Tukey’s post hoc test when ANOVA revealed a significant effect from interaction of diet and training.