Table 2.
Summary of significantly altered metaproteins.
| Microbial Metaproteins (ID) | Description | Taxonomy | Average % Abundance | p-Value | Fold Change |
|---|---|---|---|---|---|
| 87 | Phosphoenolpyruvate carboxykinase (ATP) | Superkingdom: Bacteria | 1.5 × 10−2 | 0.03 | 0.8 |
| 1176 | 5-keto-D-gluconate 5-reductase | Unknown Superkingdom | 4.6 × 10−4 | 0.04 | 1.6 |
| 3789 | Endoglucanase A | Order: Clostridiales | 3.3 × 10−4 | 0.00 | Only in WL |
| 346 | Galactokinase | Unknown Superkingdom | 2.3 × 10−4 | 0.00 | 2.5 |
| 8627 | Endoglucanase A | Species: Clostridium thermocellum | 1.3 × 10−4 | 0.04 | Only in WL |
| 1745 | Flagellin | Superkingdom: Bacteria | 9.0 × 10−5 | 0.01 | 7.7 |
| 6585 | Rubredoxin | Species: Clostridium acetobutylicum | 4.5 × 10−5 | 0.01 | Only in WL |
| 1838 | Beta-1,4-mannooligosaccharide phosphorylase | Species: Ruminococcus albus | 4.5 × 10−5 | 0.04 | Only in WL |
| 6265 | Phosphate propanoyltransferase | Species: Thermotoga maritima | 1.4 × 10−5 | 0.04 | Only in WL |
| Human Metaproteins (ID) | Description | Taxonomy | Average % Abundance | p-Value | Fold Change |
| 33 | Pancreatic alpha-amylase | Phylum: Chordata | 1.9 × 10−2 | 0.00 | 0.4 |
| 67 | Calcium-activated chloride channel regulator 1 | Class: Mammalia | 3.8 × 10−3 | 0.01 | 0.7 |
| 159 | Protein S100-A9 | Species: Homo sapiens | 2.4 × 10−4 | 0.01 | 0.6 |
| 197 | Alpha-1-antichymotrypsin | Family: Hominidae | 1.7 × 10−4 | 0.02 | 0.6 |
| 212 | Immunoglobulin kappa variable 1–33 | Species: Homo sapiens | 8.5 × 10−4 | 0.03 | 0.6 |
| 370 | Cadherin-1 | Phylum: Chordata | 6.1 × 10−4 | 0.03 | 0.5 |
| 1571 | Immunoglobulin J chain | Species: Homo sapiens | 6.1 × 10−4 | 0.02 | 1.7 |
| 169 | Neutrophil gelatinase-associated lipocalin | Species: Homo sapiens | 3.3 × 10−4 | 0.05 | 0.5 |
| 600 | Immunoglobulin kappa variable 3–15 | Species: Homo sapiens | 2.3 × 10−4 | 0.04 | 0.4 |
| 3996 | Fibrillin-1 | Class: Mammalia | 6.3 × 10−5 | 0.02 | 0.0 |
| 1852 | HLA class II histocompatibility antigen, DRB1-4 beta chain | Species: Homo sapiens | 7.6 × 10−6 | 0.04 | 0.0 |
Altered human and microbial metaproteins with an abundance > 7.6 × 10−6 are summarized. In total, 74 metaproteins were significantly changed (Table S1). Housekeeping metaproteins or unknown metaproteins were excluded. The taxonomy column shows the lowest confirmed taxonomic rank. The Wilcoxon signed-rank test was used to analyze differences in paired samples (n = 33).