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. 2021 May 12;13(10):2317. doi: 10.3390/cancers13102317

Table 5.

Arctigenin and osthole promote autophagy by upregulating Beclin-1 and LC3B-II and downregulating P62.

Effect Substance Cell Line Source
Causes autophagy Osthole MOGGCCM [64]
Upregulates Beclin-1 (mRNA) Arctigenin U87MG, T98G [61]
Upregulates Beclin-1 (protein) Arctigenin U87MG, T98G [61]
Osthole MOGGCCM [64]
Upregulates LC3B-II (mRNA) Arctigenin U87MG, T98G [61]
Upregulates LC3B-II (protein) Arctigenin U87MG [61]
Downregulates P62 (mRNA) Arctigenin U87MG, T98G [61]
Downregulates P62 (protein) Arctigenin U87MG, T98G [61]