Table 5.
Arctigenin and osthole promote autophagy by upregulating Beclin-1 and LC3B-II and downregulating P62.
| Effect | Substance | Cell Line | Source |
|---|---|---|---|
| Causes autophagy | Osthole | MOGGCCM | [64] |
| Upregulates Beclin-1 (mRNA) | Arctigenin | U87MG, T98G | [61] |
| Upregulates Beclin-1 (protein) | Arctigenin | U87MG, T98G | [61] |
| Osthole | MOGGCCM | [64] | |
| Upregulates LC3B-II (mRNA) | Arctigenin | U87MG, T98G | [61] |
| Upregulates LC3B-II (protein) | Arctigenin | U87MG | [61] |
| Downregulates P62 (mRNA) | Arctigenin | U87MG, T98G | [61] |
| Downregulates P62 (protein) | Arctigenin | U87MG, T98G | [61] |