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Xanthohumol, carnosine, and crocetin interfere with key enzymes in GBM cell metabolism.
| Effect | Substance | Cell Line(s) | Source |
|---|---|---|---|
| Downregulates HK2 (protein) | Xanthohumol | U87, T98G, LN229 | [38] |
| Decreases glucose consumption | Xanthohumol | U87, T98G, LN229 | [38] |
| Decreases lactate production | Xanthohumol | U87, T98G, LN229 | [38] |
| Downregulates (p-)GSK3β (protein) | Xanthohumol | U87 | [38] |
| Upregulates PDK4 (mRNA) | Carnosine | U87, T98G | [31] |
| Downregulates FASN (protein) | Crocetin | U87, U138, U251, U373 | [34] |
