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. 2021 May 12;11(5):402. doi: 10.3390/jpm11050402

Table 2.

Staging and Classification for the Severity of Breast Cancer-related Lymphedema.

Staging Method Staging Features Characteristics
International Society of Lymphology (ISL)
  • Physical findings

  • 0: latent/sub-clinical

  • I: spontaneously reversible

  • II: spontaneously irreversible

  • III: lymphostatic elephantiasis

  • Widely accepted

Campisi
  • Physical findings

  • I: initial/irregular edema,

  • II: persistent LE

  • III: persistent LE with lymphangitis

  • IV: fibrolymphedema

  • V: elephantiasis

  • Rely primarily on physical findings

Arm Dermal Backflow
  • ICG lymphography

  • 0: No dermal backflow

  • 1: Splash pattern around the axilla

  • 2: Stardust limited between olecranon and axilla lymphangitis

  • 3: Stardust distal to olecranon

  • 4: Stardust involving the hand

  • 5: Diffuse and stardust pattern involving the entire limb

  • Safe

  • Information regarding the lymphatic flow for LVA planning

MD Anderson
  • ICG lymphography

  • 0: No dermal backflow

  • 1: Many patent lymphatics and minimal dermal backflow

  • 2: Moderate number of patent lymphatics and segmental dermal backflow

  • 3: Few patent lymphatics with extensive dermal backflow

  • 4: Dermal backflow involving the hand

  • 5: ICG does not move proximally to injection site

  • Safe

  • Information regarding the lymphatic flow for LVA planning

Cheng’s Lymphedema grading
  • Circumferential difference and lymphoscintography

  • 0: 0–9%

  • 1: 10–19%

  • 2: 20–29%

  • 3: 30–39%

  • 4: >40%

  • Objective method

Taiwan Lymphoscintigraphy Staging
  • Lymphoscintography

  • L-0: Normal Lymphatic Drainage

  • P-1, P-2, P-3: Partial Obstruction

  • T-4, T-5, T-6: Total Obstruction

  • Validated, Reliable

LE: Lymphedema; ICG: Indocyanine Green (ICG) Lymphography; LVA: Lymphovenous anastomosis.