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. 2021 May 11;13(10):2295. doi: 10.3390/cancers13102295

Figure 2.

Figure 2

Therapy-treated obese-resistant (OB-RES) mice have a sustained reduction in tumor growth over time, whereas therapy-treated diet-induced obese (DIO) mice experience an acute response followed by tumor outgrowth. (A) Experimental design. (B) Body weights prior to tumor injection. (C) Primary tumor bioluminescence (BLI) prior to therapy administration. (D) Tumor growth over time within each treatment group. Data from n = 2–5 independent experiments per time point. Fold change values at day 27–28 compared to day 17–18 value. * denotes parametric and # denotes non-parametric test. # p < 0.05, *** p < 0.001, #### p < 0.0001. ns: non-significant, NT: no therapy, TX: AdT/CpG+αCTLA-4.