Figure 2.

Effect of treatment with RSV or RSV-LNCs on lung damage induced by LPS instillation. Mice were orally treated with ULNCs, Dexa, RSV or RSV-LNCs (5 mg/kg) 6 h after intranasal exposure to LPS (25 μg/25 μL). The lungs were perfused, and the left lobe was collected in formalin 24 h after LPS instillation. Lung sections embedded in paraffin were obtained by routine methods and stained with H and E. (A) Saline, (B) LPS, (C) +UNLC, (D) +Dexa (5 mg/kg), (E) +RSV (5 mg/kg) and (F) +RSV-LNC (5 mg/kg) microscopic images of H and E stained tissue sections. (G) Histological score analysis of lung inflammation. Data are expressed as the mean ± SEM from 6–8 animals. + p < 0.05 compared with the saline group; *** p > 0.001 compared to the LPS group.