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. 2021 May 10;13(5):683. doi: 10.3390/pharmaceutics13050683

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of treatment with RSV or RSV-LNCs on oxidative imbalance induced by LPS instillation. Mice were orally treated with ULNCs, Dexa, RSV or RSV-LNCs (5 mg/kg) 6 h after intranasal exposure to LPS (25 μg/25 μL). After 24 h of LPS instillation, fragments of right lungs were perfused and collected for analysis of (A) malondialdehyde, (B) catalase enzyme levels and posterior quantification of Nrf2 expression. (C) Representative western blot images of Nrf2 and (D) densitometric values obtained for β-actin and Nrf2 quantification, normalized to saline control (control bar; 100%). Data are expressed as the mean ± SEM from 5–8 animals. + p < 0.05, compared to saline; * p < 0.001; ** p < 0.05 and *** p < 0.0001, compared to the LPS group.