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(a) Mean arterial pressure and (b) heart rate of rats 10–14 min before infusion, during infusion, and 100 min after infusion of nanoparticles. The values represent the mean ± SEM, n = 6–7 per group. Fe3O4@PEG-Ale, Fe3O4@PEG-alendronate nanoparticles; MAP, mean arterial pressure; HR, heart rate; Bas, basal value; Inf, value determined during infusion; End, value at the end of the experiment; bpm, beats per minute.
